Neonate Feeding Regimens and the Expanding Role of Lactoferrin

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Human breast milk is the gold standard, providing a myriad of health benefits. Lactoferrin, which is found in high concentration in mammalian milk, is a multifunctional glycoprotein that has antimicrobial and immunomodulatory properties. Paolo Manzoni, MD, PhD, explains its critical role in protecting neonates against infection.

Historically, lactoferrin has been low in infant formula due to lower levels in bovine milk; however, advanced technology concentrated bovine lactoferrin in formula. Data show how much lactoferrin is needed, and when it is appropriate to supplement. Lactoferrin supplementation—human or bovine—appears to have measurable clinical benefits. Although inconsistencies exist among major RCTs in terms of lactoferrin efficacy, in study results, Dr. Manzoni identifies various heterogeneity as a cause.

Course Credit:

1.00 AANP Contact Hour
1.00 AMA PRA Category 1 CreditTM
1.00 ANCC Contact Hour
1.00 CA-BRN Contact Hour
1.00 CDR Contact Hour


Opens: 2020-06-04
Closes: 2022-06-04

Target Audience:

This activity was developed for pediatric physicians, nurses, nurse practitioners, dietitians, and other health care providers who have an interest in newborns, infants, and toddlers.

This activity is supported by an educational grant from Mead Johnson Nutrition.
  • Paolo Manzoni, MD, PhD

    Division of Pediatrics and Neonatology
    Department of Maternal-Infant Medicine
    Nuovo Ospedale degli Infermi
    Ponderano (Biella), Italy

    Board of Directors
    Neonatal Infectious Disease Group of the Italian Society of Neonatology

Learning Objectives

  • Evaluate clinical research that is expanding the understanding of the physiological and developmental properties of lactoferrin
  • Develop evidence-based NICU feeding regimens with lactoferrin

Faculty Disclosures

Paolo Manzoni, MD, PhD

  • Speakers Bureau
    • Sodilac – Clinical area: Lactoferrin use in infants
    • Mead Johnson Nutrition – Clinical area: Infant Nutrition

Accreditation and Certification

The Annenberg Center for Health Sciences at Eisenhower is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Annenberg Center for Health Sciences at Eisenhower designates this activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The Annenberg Center for Health Sciences is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 040207.
This program is designated for up to 1.00 contact hour. Program ID# 5729-EM.
The Annenberg Center for Health Sciences is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
A maximum of 1.00 contact hour may be earned for successful completion of this activity.
Provider is approved by the California Board of Registered Nursing, Provider #13664, for 1.00 contact hour.
To receive credit for education contact hours outside of the state of California, please check with your state board of registered nursing for reciprocity.
Annenberg Center for Health Sciences at Eisenhower is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration (CDR). Registered dietitians (RDs) and dietetic technicians, registered (DTRs) will receive 1.00 hour continuing professional education unit (CPEU) for completion of this program/material.
Provider Number AC857; Activity Number 155851.
Learners may submit additional evaluations of the quality of this program/material to

Additional Content Planners

Erin Allen, MS, RD, LDN (Dietitian Reviewer)
No significant relationships to disclose.

Victoria Anderson (Medical Writer)
  • Individual Stockholder
    • Abbott 
    • AbbVie

Coy Flowers, MD (Peer Reviewer)
No significant relationships to disclose.

Heather M. Jimenez, FNP-C (Nurse Planner)
No significant relationships to disclose.

Annenberg Center for Health Sciences

All staff at the Annenberg Center for Health Sciences at Eisenhower have no relevant commercial relationships to disclose.