Confronting the Allergic March

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This education is about:

  • Etiology of the allergic march
  • Role of the microbiome in development of the immune and gastrointestinal systems 
  • The link between intestinal permeability and food allergy 
  • Presentation and diagnosis of cow’s milk protein allergy (CMPA)
  • Novel strategies for management of CMPA
  • Techniques that encourage development of cow’s milk allergen tolerance

Why it matters:
Cow’s milk protein allergy (CMPA) is a common diagnosis among infants and can develop as a part of the allergic march. In recent years, a better understanding of the allergic march has led to the identification of the gut microbiome and intestinal permeability as important drivers of allergen sensitization. Early interventions that target colonization of the gut microbiome and support an optimal gut barrier may help to both prevent CMPA and accelerate the induction of tolerance to cow’s milk protein. These strategies can ultimately improve the outcomes and quality of life of infants and families.

Target Audience:

Pediatricians, pediatric nurses, dietitians, and other healthcare providers who treat infants and children

Course Credit:

1 AMA PRA Category 1 CreditTM
1 ANCC Contact hour(s)
1 CA-BRN Contact hour(s)
1 CDR Contact hour(s)
0.75 Pharmacology hour(s).


Opens: 2023-07-26
Closes: 2025-07-26

This activity is supported by an educational grant from Reckitt | Mead Johnson Nutrition.
  • Alessio Fasano, MD

    W. Allan Walker Chair of Pediatric Gastroenterology and Nutrition
    Professor of Pediatrics, Harvard Medical School
    Professor of Nutrition, Harvard T.H. Chan School of Public Health
    Chief of the Division of Pediatric Gastroenterology and Nutrition 
    Associate Chief for Research, Department of Pediatrics
    MassGeneral Hospital for Children 
    Director of the Center for Celiac Research and Treatment
    Director of the Mucosal Immunology and Biology Research Center
    Massachusetts General Hospital - East

Learning Objectives

  • Understand the Allergic March and the role of gut microbiome dysbiosis as a critical factor underlying food allergy
  • Describe the prevalence, risk factors, clinical presentation, and diagnostic approach for cow milk protein allergy (CMPA)
  • Apply novel strategies for management of CMPA, including new techniques to accelerate milk allergen tolerance